Hepatology

Maddrey's Discriminant Function

Identifies patients with severe alcoholic hepatitis who may benefit from corticosteroid therapy. A discriminant function ≥ 32 marks a 30-day mortality risk near 50% in untreated patients.

Patient prothrombin time (seconds)

Control prothrombin time (seconds)

Total bilirubin

Source

Maddrey WC, Boitnott JK, Bedine MS, Weber FL Jr, Mezey E, White RI Jr. Corticosteroid therapy of alcoholic hepatitis. Gastroenterology 1978.

PMID 352788 Ask House about this