acellular pertussis vaccine

Acellular pertussis vaccine incorporates antigen fragments derived from Bordetella pertussis. The native pertussis toxin's A subunit, once in the cell cytosol, ADP-ribosylates the α subunit of the Gi protein, which normally couples inhibitory G protein-coupled receptor signaling to adenylyl cyclase to reduce cyclic AMP production. This action contributes to the symptoms of whooping cough.

Adult

appropriate to immunize healthy adults, adolescents, and pregnant mothers as pertussis does occur throughout life due to waning immunity

Pediatric

routine vaccination typically begins as part of the childhood combination DTaP vaccine series