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alefacept

Anti-CD2 monoclonal antibody · Immunosuppressant

Anti-CD2 monoclonal antibodyImmunosuppressant
CDSCO approved
EXCRETION
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
not curated
Top interactionssee all 12
  • BaricitinibSevereDatabaseDDInter
  • CladribineSevereDatabaseDDInter
  • FingolimodSevereDatabaseDDInter
  • LeflunomideSevereDatabaseDDInter

Mechanism

Human LFA-3–IgG1 fusion protein. The LFA-3 portion of alefacept binds to CD2 on T lymphocytes, blocking the interaction between LFA-3 and CD2 and interfering with T-cell activation.

Indications

psoriasis

Drug interactions

Baricitinib
Severe
Database

Drug interaction classified as: others

Source: DDInter

Cladribine
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Fingolimod
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Leflunomide
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Measles Virus Vaccine Live Attenuated
Severe
Database

Drug interaction classified as: others

Source: DDInter

Mumps Virus Strain B Level Jeryl Lynn Live Antigen
Severe
Database

Drug interaction classified as: others

Source: DDInter

Natalizumab
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Ozanimod
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Rotavirus Vaccine
Severe
Database

Drug interaction classified as: others

Source: DDInter

Rubella Virus Vaccine
Severe
Database

Drug interaction classified as: others

Source: DDInter

Siponimod
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Talimogene Laherparepvec
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Related guidelines

Ask House about alefacept

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Sources: Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team