Drug reference

altretamine

ethyleneimine, methylmelamine · anticancer

ethyleneimine, methylmelamineanticancer

CDSCO approved

EXCRETION

—

not curated

INTERACTIONS

12 major

SEVERE in our sources

PREGNANCY

—

not curated

Top interactionssee all 12 →

MoclobemideSevereTextbookG&G 14e · p1349
ProcarbazineSevereTextbookG&G 14e · p1349
RasagilineSevereTextbookG&G 14e · p1349
SelegilineSevereTextbookG&G 14e · p1349

Mechanism

Altretamine is structurally similar to TEM. Its precise mechanism of cytotoxicity is unknown, but it can alkylate DNA and proteins. The methylmelamines are N-demethylated by hepatic microsomes with the release of formaldehyde.

Indications

persistent or recurrent ovarian cancer (palliative treatment following cisplatin-based combination therapy)

Pharmacokinetics

Onset

not specified

Peak effect

not specified

Bioavailability

well absorbed from the GI tract

Protein binding

not specified

Metabolism

undergoes rapid demethylation in the liver; principal metabolites are pentamethylmelamine and tetramethylmelamine

Side effects

Common

myelosuppressionneurotoxicity (peripheral and central, including ataxia, depression, confusion, drowsiness, hallucinations, dizziness, vertigo)nauseavomitingrashes (rare)alopecia (rare)hepatic toxicity (rare)

Serious

severe, life-threatening orthostatic hypotension (with concurrent monoamine oxidase inhibitors, amitriptyline, imipramine, or phenelzine)
renal dysfunction (may necessitate discontinuing the drug)

Drug interactions

Moclobemide

Severe

Textbook

Severe, life-threatening orthostatic hypotension.

Not specified, but implies avoidance due to severe, life-threatening effect.

Source: G&G 14e · p1349

Procarbazine

Severe

Textbook

Severe, life-threatening orthostatic hypotension.

Not specified, but implies avoidance due to severe, life-threatening effect.

Source: G&G 14e · p1349

Rasagiline

Severe

Textbook

Severe, life-threatening orthostatic hypotension.

Not specified, but implies avoidance due to severe, life-threatening effect.

Source: G&G 14e · p1349

Selegiline

Severe

Textbook

Severe, life-threatening orthostatic hypotension.

Not specified, but implies avoidance due to severe, life-threatening effect.

Source: G&G 14e · p1349

Adalimumab

Severe

Database