Ciprofloxacin
Moderate
Textbook-cited
Therapeutic failure of the antibiotic
Stagger administration by 2-3 hours
Source: KDT 7e · p949
Drug reference
aluminium hydroxide
Nonsystemic antacid · Antacid
Nonsystemic antacidAntacid
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
—
none in our sources
PREGNANCY
—
not curated
Mechanism
Aluminium hydroxide is a bland, weak, and slowly reacting antacid. It can polymerize, reducing its reactivity. It relaxes smooth muscle, delaying gastric emptying, and binds phosphate in the intestine.
Indications
AntacidHyperphosphatemiaPhosphate stonesComponent in antacid combinations
Side effects
Common
Constipation
Serious
- Hypophosphatemia (on regular use, can cause osteomalacia)
- Aluminium toxicity (encephalopathy, osteoporosis) in renal failure
Drug interactions
Doxycycline
Moderate
Textbook-cited
Therapeutic failure of the antibiotic
Stagger administration by 2-3 hours
Source: KDT 7e · p949
Levofloxacin
Moderate
Textbook-cited
Therapeutic failure of the antibiotic
Stagger administration by 2-3 hours
Source: KDT 7e · p949
Minocycline
Moderate
Textbook-cited
Therapeutic failure of the antibiotic
Stagger administration by 2-3 hours
Source: KDT 7e · p949
Moxifloxacin
Moderate
Textbook-cited
Therapeutic failure of the antibiotic
Stagger administration by 2-3 hours
Source: KDT 7e · p949
Norfloxacin
Moderate
Textbook-cited
Therapeutic failure of the antibiotic
Stagger administration by 2-3 hours
Source: KDT 7e · p949
Ofloxacin
Moderate
Textbook-cited
Therapeutic failure of the antibiotic
Stagger administration by 2-3 hours
Source: KDT 7e · p949
Tetracycline
Moderate
Textbook-cited
Therapeutic failure of the antibiotic
Stagger administration by 2-3 hours
Source: KDT 7e · p949
Isoniazid
Moderate
Textbook
Reduced isoniazid blood levels and potential decrease in its antitubercular efficacy.
Not explicitly stated, but implying separate administration or adjustment if concomitant use is necessary.
Source: KDT 7e · p767
Nitrofurantoin
Moderate
Database
Decreased efficacy of nitrofurantoin, potentially leading to treatment failure for urinary tract infections.
Separate administration by at least 2-3 hours. Consider alternative antacids if frequent use is required.
Related guidelines
Other Nonsystemic antacid drugs
Ask House about aluminium hydroxide
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e·Verified: 2026-05-10 · House clinical team