Alfentanil
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Drug reference
Amobarbital
Sedative-Hypnotic · Hypnotic
Also known as AMYTAL, Amobarbital sodium
Sedative-HypnoticHypnotic
CDSCO approvedSchedule X
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
- AlfentanilSevereDatabaseDDInter
- AnisindioneSevereDatabaseDDInter
- BenzhydrocodoneSevereDatabaseDDInter
- BuprenorphineSevereDatabaseDDInter
Mechanism
Amobarbital, an intermediate-acting barbiturate, produces sedative-hypnotic effects useful for severe intractable insomnia and pre-operative sedation. Its mechanism of action leads to central nervous system depression and is not antagonized by flumazenil, distinguishing it from benzodiazepines.
Indications
Severe intractable insomnia (in patients already taking barbiturates)InsomniaPre-operative sedationEmergency management of seizuresPreoperative sedation
Dosing
- Geriatric
- Avoided in the elderly
Pharmacokinetics
Half-life
10-40 hours
Metabolism
Cytochrome P450-dependent aliphatic hydroxylations
Contraindications
- Avoided in the elderly
Drug interactions
Anisindione
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Benzhydrocodone
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Buprenorphine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Butorphanol
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Codeine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Dextropropoxyphene
Severe
Database
Drug interaction classified as: synergy, metabolism
Source: DDInter
Dezocine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Dicoumarol
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Dihydrocodeine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Ethanol
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Fentanyl
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Related guidelines
Preoperative cardiac evaluation for non-cardiac surgery
AHA · Cardiology · 2025
Functional (psychogenic non-epileptic) seizures
AAN · Neurology · 2026
Dengue fever
ICMR · Infectious Disease · 2022
Snakebite envenomation
MOHFW · Emergency Medicine · 2021
Initial monotherapy for newly diagnosed epilepsy
ILAE · Neurology · 2013
Other Sedative-Hypnotic drugs
Ask House about Amobarbital
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Goodman & Gilman 14e, Katzung, BNF·Verified: 2026-05-10 · House clinical team