arteether

Arteether is an artemisinin derivative. The endoperoxide bridge in its molecule interacts with heme in the parasite, causing ferrous iron-mediated cleavage and release of highly reactive free radical species. These free radicals bind to membrane proteins, cause lipid peroxidation, damage endoplasmic reticulum, and ultimately result in lysis of the parasite. It is a potent and rapid blood schizontocide.

Adult

Severe/complicated falciparum (IM): 3.2 mg/kg on day 1, followed by 1.6 mg/kg daily for the next 4 days (switch to 3-day oral ACT when possible).