Drug reference
arterolane
Sesquiterpine lactone (synthetic derivative) · Antimalarial
Sesquiterpine lactone (synthetic derivative)Antimalarial
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
—
none in our sources
PREGNANCY
—
not curated
Mechanism
Arterolane is a novel orally active synthetic trioxolane congener of artemisinin. It acts rapidly at all stages of asexual schizogony of the malarial parasite, including multidrug resistant P. falciparum. It accumulates in the food vacuole of the parasite. It also possesses moderate gametocidal activity.
Indications
uncomplicated CQ-resistant falciparum malaria (as part of ACT)Uncomplicated falciparum malaria (in combination with piperaquine as FDC)
Dosing
- Adult
- Uncomplicated CQ-resistant falciparum: 150 mg + Piperaquine 750 mg once daily × 3 days.
Pharmacokinetics
Peak effect
3–5 hours
Half-life
1–3 hours
Protein binding
Well absorbed orally, large volume of distribution
Metabolism
Major metabolic pathway is oxidation, mainly by CYP3A4
Side effects
Common
Mild headachePostural dizzinessVomitingAbdominal painDiarrhoea
Related guidelines
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Sources: KD Tripathi 7e·Verified: 2026-05-10 · House clinical team