Drug reference

avanafil

PDE5 inhibitor

CDSCO approved

EXCRETION

—

not curated

INTERACTIONS

12 major

incl. contraindicated

PREGNANCY

—

not curated

Top interactionssee all 12 →

Organic NitratesContraindicatedTextbookG&G 14e · p999
Isosorbide MononitrateContraindicatedDatabaseDDInter
AmprenavirSevereDatabaseDDInter
Amyl NitriteSevereDatabaseDDInter

Mechanism

Avanafil inhibits cyclic GMP–selective phosphodiesterase (PDE) 5.

Indications

erectile dysfunctionpulmonary hypertension

Drug interactions

Organic Nitrates

Contraindicated

Textbook

Dangerously low blood pressures.

The administration of PDE5 inhibitors to patients receiving organic nitrates is contraindicated. The patient’s underlying cardiovascular status and concurrent use of hypotensive agents (e.g., nitrates, α adrenergic antagonists) must be considered prior to use of this class of drugs.

Source: G&G 14e · p999

Isosorbide Mononitrate

Contraindicated

Database

Profound and prolonged systemic hypotension, syncope, myocardial ischemia, and even death.

Concomitant use is absolutely contraindicated. A minimum of 12 hours should elapse between the last dose of avanafil and the administration of isosorbide mononitrate.

Source: DDInter

Amprenavir

Severe

Database

Drug interaction classified as: metabolism

Source: DDInter

Amyl Nitrite

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Aprepitant