Drug reference

Cabazitaxel

Taxane · Antineoplastic

Also known as Jevtana

TaxaneAntineoplastic

CDSCO approvedSchedule H

EXCRETION

—

not curated

INTERACTIONS

12 major

SEVERE in our sources

PREGNANCY

See also Pregnancy and reproductive function

FDA category + note

Top interactionssee all 12 →

AdalimumabSevereDatabaseDDInter
BaricitinibSevereDatabaseDDInter
CertolizumabSevereDatabaseDDInter
CladribineSevereDatabaseDDInter

Mechanism

Cabazitaxel, as a taxane, exerts its antineoplastic effect by binding to and stabilizing microtubules. This action prevents the depolymerization of microtubules, disrupting the dynamic equilibrium necessary for proper mitotic spindle formation and function during cell division. The resultant mitotic arrest at metaphase and subsequent inhibition of cell replication leads to cell cycle arrest and apoptosis in rapidly proliferating cancer cells.

Indications

Treatment of hormone refractory metastatic prostate cancer in patients who have previously been treated with a docetaxel-containing regimen (in combination with prednisone or prednisolone)Hormone-refractory metastatic prostate cancer (previously treated with a docetaxel-containing regimen)

Dosing

Adult: l INDICATIONS AND DOSE Treatment of hormone refractory metastatic prostate cancer in patients who have previously been treated with a docetaxel-containing regimen (in combination with prednisone or prednisolone) ▶ BY INTRAVENOUS INFUSION ▶ Adult: (consult product literature or local protocols) Avoid in Acute porphyrias p.…

Pharmacokinetics

Metabolism

Substrate for CYP2C8

Contraindications

Acute porphyrias

Side effects

Common

Acute kidney injuryalopeciaanaemiaanxietyappetite decreasedarrhythmiasarthralgiaastheniachest painchillsconfusionconjunctivitisconstipationcoughcystitisdeep vein thrombosisdehydrationdiarrhoeadizzinessdry mouthdyspnoeaexcessive tearingfevergastrointestinal discomfortgastrointestinal disordershaemorrhageheadachehydronephrosishyperglycaemiahypersensitivityhypertensionhypokalaemiahypotensionincreased risk of infectionlethargymalaisemucositisnauseaneutropeniaskin reactionsthrombocytopeniavomitinganaphylactic reactioninfectionoesophagitisstomatitis

Serious