Drug reference

Calcium Acetate

Phosphate Binder · Hyperphosphataemia agent

Also known as Phosex, Renacet, Calphron, Phoslyra, PhosLo

Phosphate BinderHyperphosphataemia agent

CDSCO approvedSchedule H

EXCRETION

—

not curated

INTERACTIONS

3 major

SEVERE in our sources

PREGNANCY

—

not curated

Top interactions

BictegravirSevereDatabaseDDInter
DolutegravirSevereDatabaseDDInter
ErdafitinibSevereDatabaseDDInter

Mechanism

Calcium acetate works as a phosphate binder. It dissociates in the acidic environment of the stomach to release calcium ions, which then bind to dietary phosphate in the gastrointestinal tract to form insoluble calcium phosphate. This insoluble complex is then excreted in the feces, preventing its absorption and thereby reducing serum phosphate levels. One gram of calcium acetate binds to 45 mg of phosphorus.

Indications

HyperphosphataemiaControl of hyperphosphataemia in patients with chronic kidney disease on haemodialysis or peritoneal dialysisCKD-Mineral Bone Disorder/secondary hyperparathyroidism (as a phosphate binder)restrict phosphate absorption in chronic kidney disease (CKD)treatment and prevention of chronic kidney disease–mineral bone disease (CKD-MBD)

Dosing

Adult: Initially 1 tablet 3 times a day, to be taken with meals, dose to be adjusted according to serum-phosphate concentration, usual dose 4–6 tablets daily in divided doses (1 or 2 tablets with each meal). Alternatively, start with 1334 mg PO with each meal.…
Pediatric: Child and adolescent: Start with 667–1000 mg PO with each meal. If needed, dosage may be titrated every 2–4 weeks up to a maximum elemental calcium intake of 1500 mg/24 hr from phosphate binders, and total calcium intake of 2000 mg/24 hr from all sources.
Renal adjustment: Use with caution in renal impairment, as hypercalcemia may develop in end-stage renal failure.
Max dose: 12 tablets per day (Phosex/Renacet)