Bictegravir
Severe
Database
Clinical effect not specified
Source: DDInter
Drug reference
Calcium lactate
Calcium salt supplement (oral) · Mineral supplement
Also known as Cal-Lac
START
Elemental calcium 500 mg/day with food
TYPICAL MAX
Total intake ~2000–2500 mg elemental calcium/day
STOP IF
Hypercalcaemia, renal stones, or persistent constipation
WATCH
Serum/urinary calcium if high-dose; phosphate in CKD
CDSCO approvedOTCATC A12AA05
KDIGO 2024 + manufacturer label
- ONSET
- 1w · repletion
- PEAK
- 2w · store effect
- t½
- 36s · homeostatic
- DURATION
- 1d · daily dosing
EXCRETION
Renal and faecal — homeostatic
route + CYP
INTERACTIONS
2 major
SEVERE in our sources
PREGNANCY
Safe at recommended intakes.
FDA category + note
Top interactionssee all 6 →
- BictegravirSevereDatabaseDDInter
- DolutegravirSevereDatabaseDDInter
Mechanism
Provides elemental calcium (~13% by weight) for bone mineralisation and to correct/prevent calcium deficiency states; lactate moiety is metabolised.
Indications
Dietary calcium supplementationMild–moderate hypocalcaemia (oral)Adjunct in osteoporosis/osteomalacia
Dosing
- Adult
- Elemental calcium 500–1000 mg/day in divided doses with meals.
- Pediatric
- Per age-specific calcium requirement.
- Renal adjustment
- Caution in CKD-MBD; specialist guidance for replacement.
- Hepatic adjustment
- No adjustment.
- Geriatric
- Common osteoporosis component; avoid excess.
- Max dose
- Total elemental calcium intake ~2000–2500 mg/day (all sources)
Pharmacokinetics
Onset
Repletion over weeks
Peak effect
Serum calcium tightly regulated
Duration
Dosing-dependent
Half-life
Not applicable (physiologic homeostasis)
Bioavailability
~25–30% (vitamin D / pH dependent)
Protein binding
~40% (serum albumin-bound calcium)
Metabolism
Lactate metabolised; calcium not metabolised
Excretion
Renal and faecal — homeostatically regulated
Contraindications
- Hypercalcaemia
- Severe hypercalciuria / calcium-stone disease
- Renal calculi (calcium-containing)
- Hypersensitivity
Side effects
Common
ConstipationBloatingNauseaMild dyspepsia
Serious
- Hypercalcaemia (excess intake)
- Renal calculi (chronic excess)
- Milk-alkali syndrome (excess with alkali)
Pregnancy & lactation
Pregnancy
Safe at recommended intakes.
Lactation
Compatible at recommended intakes.
Drug interactions
Dolutegravir
Severe
Database
Clinical effect not specified
Source: DDInter
Digoxin
Moderate
Database
Hypercalcaemia potentiates digoxin
Avoid hypercalcaemia; monitor
Source: Kimi deep-research + Cla
Levothyroxine
Moderate
Database
Reduced absorption
Separate dosing widely
Source: Kimi deep-research + Cla
Tetracyclines
Moderate
Database
Calcium chelation
Separate by ≥2–4 h
Source: Kimi deep-research + Cla
Thiazide Diuretics
Moderate
Database
Reduced calcium excretion
Monitor serum calcium
Source: Kimi deep-research + Cla
6 additional low-confidence interactions hidden — those rows lack a documented mechanism or management plan in our sources.
Related guidelines
Iron deficiency anaemia in pregnancy
ICMR · Obstetrics & Gynaecology · 2022
Iron deficiency anaemia in adults
ICMR · Hematology · 2023
Chronic kidney disease — mineral and bone disorder
KDIGO · Nephrology · 2017
Infant and child nutrition
ICMR · Pediatrics · 2024
Antenatal care
FOGSI · Obstetrics & Gynaecology · 2019
Ask House about Calcium lactate
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e, Katzung, BNF, Harriet Lane·Verified: 2026-05-20 · House clinical team·Cockpit curated: 2026-05-20