Amikacin
Severe
Database
Clinical effect not specified
Source: DDInter
Drug reference
Capreomycin
Antimycobacterial · Antituberculosis
Also known as Capreomycin sulfate, CAPASTAT
AntimycobacterialAntituberculosis
CDSCO approvedSchedule H
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
Use only if potential benefit outweighs risk; teratogenic in animal studies.
FDA category + note
Top interactionssee all 12 →
- AmikacinSevereDatabaseDDInter
- AmiodaroneSevereDatabaseDDInter
- Arsenic TrioxideSevereDatabaseDDInter
- CidofovirSevereDatabaseDDInter
Mechanism
Capreomycin is an antimycobacterial cyclic peptide whose activity is similar to that of aminoglycosides.
Indications
Tuberculosis resistant to first-line drugs, in combination with other drugshard-to-treat nontuberculous mycobacterial infectionsdrug-resistant mycobacterium avium complexmycobacterium abscessusMDR-TB (as an alternative to aminoglycoside antibiotics, many streptomycin and amikacin resistant strains remain susceptible)
Dosing
- Adult
- BY DEEP INTRAMUSCULAR INJECTION: 1 g daily (max. per dose 20 mg/kg) for 2–4 months (or 60-120 days), then reduced to 1 g 2–3 times a week.
- Renal adjustment
- Reduce dose—consult product literature. Manufacturer advises caution if eGFR less than 30 mL/minute/1.73 m2.
- Hepatic adjustment
- Manufacturer advises caution in moderate impairment; avoid in severe impairment (no information available).
- Max dose
- 20 mg/kg per day
Contraindications
- Auditory impairment
Side effects
Common
Eosinophiliafebrile disorderspainskin reactionsleucocytosisleukopeniarashesfeverpain with injectiontinnitustransient proteinuriacylindrurianitrogen retentionleukocytosisrashInjection site pain
Serious
- Hearing impairment
- nephrotoxicity
- pseudo-Bartter syndrome
- thrombocytopenia
- tinnitus
- vertigo
- severe renal failure
- transient proteinuria
- cylindruria
- nitrogen retention
- hearing loss
- severe renal failure (rare)
- Ototoxicity
Pregnancy & lactation
Pregnancy
Use only if potential benefit outweighs risk; teratogenic in animal studies.
Lactation
Manufacturer advises caution as it is present in milk in animal studies; avoid.
Drug interactions
Amiodarone
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Arsenic Trioxide
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Cidofovir
Severe
Database
Clinical effect not specified
Source: DDInter
Deferasirox
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Diatrizoate
Severe
Database
Clinical effect not specified
Source: DDInter
Dofetilide
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Dronedarone
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Droperidol
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Everolimus
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Gentamicin
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Human Cytomegalovirus Immune Globulin
Severe
Database
Clinical effect not specified
Source: DDInter
Related guidelines
Other Antimycobacterial drugs
Ask House about Capreomycin
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e, Goodman & Gilman 14e, Katzung, BNF·Verified: 2026-05-10 · House clinical team