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cefamandole

Second-generation cephalosporin · Antibacterial; Cephalosporin

Second-generation cephalosporinAntibacterial; Cephalosporin
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
1 major
SEVERE in our sources
PREGNANCY
B
FDA category + note
Top interactions
  • RifampicinSevereDatabaseDDInter

Mechanism

Inhibits bacterial cell-wall synthesis.

Side effects

Common
Gastrointestinal side effects (e.g., diarrhea)
Serious
  • Hypersensitivity reactions (rash to anaphylaxis)
  • Serum sickness
  • Stevens-Johnson syndrome
  • Nephropathy
  • Hematologic reactions (neutropenia, prolonged use)
  • Neurotoxicity (seizure, high doses, renal impairment)

Pregnancy & lactation

Pregnancy

B

Drug interactions

Rifampicin
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

11 additional low-confidence interactions hidden — those rows lack a documented mechanism or management plan in our sources.

Related guidelines

Stroke and TIA — secondary prevention
AHA · Neurology · 2021
Dyslipidaemia management
ICMR · Cardiology · 2023
Glomerular diseases
KDIGO · Nephrology · 2021
Dyslipidaemia management
ESC · Cardiology · 2019
Dyslipidaemia management
AHA · Cardiology · 2018

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Sources: Harrison 22e·Verified: 2026-05-10 · House clinical team