Rifampicin
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Drug reference
cefotetan
Cephalosporin (Second-Generation, Cephamycin) · Antibacterial, β-Lactam Antibiotic, Cell Wall Synthesis Inhibitor (Second-Generation Cephalosporin, Cephamycin)
Cephalosporin (Second-Generation, Cephamycin)Antibacterial, β-Lactam Antibiotic, Cell Wall Synthesis Inhibitor (Second-Generation Cephalosporin, Cephamycin)
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
1 major
SEVERE in our sources
PREGNANCY
B
FDA category + note
Top interactions
- RifampicinSevereDatabaseDDInter
Mechanism
Not yet extracted
Indications
Gynecologic infectionsPerioperative surgical prophylaxis (intra-abdominal and gynecological surgical procedures)Anaerobic and mixed aerobic-anaerobic infections (e.g., peritonitis and pelvic inflammatory disease)Pelvic Inflammatory Disease (PID)
Dosing
- Adult
- For Pelvic Inflammatory Disease (PID) (inpatient): 2 g IV q12h (with doxycycline), continuing for at least 48 h after clinical improvement, then oral doxycycline to complete 14 days.
- Renal adjustment
- Not specified in this chapter.
Side effects
Common
Gastrointestinal side effects (e.g., diarrhea)
Serious
- Hypersensitivity reactions (rash to anaphylaxis)
- Serum sickness
- Stevens-Johnson syndrome
- Nephropathy
- Hematologic reactions (neutropenia, prolonged use)
- Neurotoxicity (seizure, high doses, renal impairment)
Pregnancy & lactation
Pregnancy
B
Drug interactions
11 additional low-confidence interactions hidden — those rows lack a documented mechanism or management plan in our sources.
Related guidelines
Inflammatory bowel disease
OTHER · Gastroenterology · 2015
Intra-abdominal infection
WSES · Surgery · 2017
Skin and soft tissue infections
IDSA · Infectious Diseases · 2010
Acute dental pain and intraoral swelling
ADA_DENTAL · Dentistry · 2019
Infective endocarditis prevention
NICE · Cardiology / Dentistry · 2008
Ask House about cefotetan
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Goodman & Gilman 14e, Harrison 22e·Verified: 2026-05-10 · House clinical team