Drug reference

ceftaroline

Cephalosporin (Anti-MRSA) · Antibacterial, β-Lactam Antibiotic, Cell Wall Synthesis Inhibitor (Anti-MRSA Cephalosporin)

Cephalosporin (Anti-MRSA)Antibacterial, β-Lactam Antibiotic, Cell Wall Synthesis Inhibitor (Anti-MRSA Cephalosporin)

CDSCO approved

EXCRETION

—

not curated

INTERACTIONS

—

none in our sources

PREGNANCY

FDA category + note

Mechanism

Ceftaroline has structural modifications allowing for binding to and inactivation of the altered PBPs expressed by MRSA, MRSE, and penicillin-resistant S. pneumoniae. It has enhanced gram-positive activity, especially its ability to bind to the low-affinity PBPs.

Indications

Community-acquired pneumoniaSkin and soft-tissue infectionsNosocomial pneumoniasSkin and soft tissue infections (SSTIs)Invasive MRSA infections (with or without glycopeptides)Methicillin-resistant strains with intermediate or complete resistance to vancomycin (alone or in combination with daptomycin)Salvage therapy for persistent MRSA bacteremia (in combination with daptomycin or vancomycin)