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cefuroxime axetil

Second generation cephalosporin · Antibiotic

Second generation cephalosporinAntibiotic
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
—
none in our sources
PREGNANCY
B
FDA category + note

Mechanism

Not yet extracted

Indications

Same as cefuroxime after hydrolysis in vivo

Pharmacokinetics

Bioavailability
oral effective, though absorption is incomplete
Metabolism
activity depends on in vivo hydrolysis and release of cefuroxime

Side effects

Common
Gastrointestinal side effects (e.g., diarrhea)
Serious
  • Hypersensitivity reactions (rash to anaphylaxis)
  • Serum sickness
  • Stevens-Johnson syndrome
  • Nephropathy
  • Hematologic reactions (neutropenia, prolonged use)
  • Neurotoxicity (seizure, high doses, renal impairment)

Pregnancy & lactation

Pregnancy

B

Drug interactions

Famotidine
Moderate
Database

Reduced plasma concentrations of cefuroxime, potentially leading to decreased antibacterial efficacy.

If possible, separate administration of cefuroxime axetil from famotidine by at least 2 hours. Monitor for signs of infection and clinical response.

Related guidelines

Stroke and TIA — secondary prevention
AHA · Neurology · 2021
Acute dental pain and intraoral swelling
ADA_DENTAL · Dentistry · 2019
Infective endocarditis prevention
ADA_DENTAL · Dentistry · 2015
Community-acquired pneumonia
ICMR · Pulmonology · 2022
Extrapulmonary tuberculosis
ICMR · Infectious Diseases · 2022

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Sources: KD Tripathi 7e, Harrison 22e·Verified: 2026-05-10 · House clinical team