Drug reference
clonidine (oral)
Central α2-agonist and other centrally acting drugs
Central α2-agonist and other centrally acting drugs
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
—
none in our sources
PREGNANCY
C
FDA category + note
Mechanism
Stimulates central nervous system α2-adrenergic receptors.
Indications
Hypertension
Dosing
- Adult
- 0.1–0.8 mg twice daily
Side effects
Common
SedationDry mouthBradycardiaFatigueConstipationOrthostatic hypotension
Serious
- Hypertensive crisis following abrupt withdrawal
Pregnancy & lactation
Pregnancy
C
Related guidelines
Other Central α2-agonist and other centrally acting drugs drugs
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Textbook-sourced·Sources: Harrison 22e·Updated: 2026-05-10