Mycophenolate Mofetil
Severe
Database
Drug interaction classified as: absorption
Source: DDInter
Drug reference
colestipol
Bile Acid Sequestrant · Antihyperlipidemic
Bile Acid SequestrantAntihyperlipidemic
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
5 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
- Mycophenolate MofetilSevereDatabaseDDInter
- Mycophenolic AcidSevereDatabaseDDInter
- TeriflunomideSevereDatabaseDDInter
- ThyroxineSevereDatabase
Mechanism
Colestipol is highly positively charged and binds negatively charged bile acids in the intestine, preventing their reabsorption and promoting excretion in stool. This depletes the bile acid pool, stimulating hepatic bile acid synthesis and increasing LDL receptor production, which enhances LDL-C clearance from plasma. This effect is partially offset by enhanced cholesterol synthesis.
Indications
HyperlipidemiaSecond-line agent if statin therapy insufficient or in statin intolerancePatients 11-20 years of ageRetard atherosclerosis
Dosing
- Adult
- 10 to 15 g daily (divided doses), starting with 1 scoop or packet twice daily and increasing dosage as needed and tolerated. Maximal dose up to 30 g daily.
Pharmacokinetics
Metabolism
Neither digested nor absorbed in the gut.
Contraindications
- Severe hypertriglyceridemia (>250 mg/dL baseline)
Side effects
Common
Gritty sensation when drinking slurryBloatingDyspepsiaConstipationFlatulenceGastrointestinal symptoms
Serious
- Hyperchloremic acidosis (rare)
Drug interactions
Mycophenolic Acid
Severe
Database
Drug interaction classified as: absorption
Source: DDInter
Teriflunomide
Severe
Database
Drug interaction classified as: absorption, metabolism
Source: DDInter
Thyroxine
Severe
Database
Significantly decreased thyroxine efficacy, leading to severe hypothyroidism symptoms or increased TSH levels
Administer thyroxine at least 4-5 hours before or after colestipol. Monitor TSH levels closely and adjust thyroxine dose as needed.
Ursodeoxycholic Acid
Severe
Database
Decreased efficacy of ursodeoxycholic acid.
Administer ursodeoxycholic acid at least 2 hours before or 4-6 hours after colestipol. Monitor for therapeutic effect.
Alirocumab
Moderate
Textbook
Reduced efficacy of statins.
Patients should take other medications 1 h before or 3 to 4 h after a dose of colestipol.
Source: G&G 14e · p738
Atorvastatin + Aspirin
Moderate
Textbook
Reduced efficacy of statins.
Patients should take other medications 1 h before or 3 to 4 h after a dose of colestipol.
Source: G&G 14e · p738
Evolocumab
Moderate
Textbook
Reduced efficacy of statins.
Patients should take other medications 1 h before or 3 to 4 h after a dose of colestipol.
Source: G&G 14e · p738
L Thyroxine
Moderate
Textbook
Reduced efficacy of l-thyroxine.
Patients should take other medications 1 h before or 3 to 4 h after a dose of colestipol.
Source: G&G 14e · p738
Lovastatin
Moderate
Textbook
Reduced efficacy of statins.
Patients should take other medications 1 h before or 3 to 4 h after a dose of colestipol.
Source: G&G 14e · p738
Methyclothiazide
Moderate
Textbook
Reduced efficacy of thiazides.
Patients should take other medications 1 h before or 3 to 4 h after a dose of colestipol.
Source: G&G 14e · p738
Mevastatin
Moderate
Textbook
Reduced efficacy of statins.
Patients should take other medications 1 h before or 3 to 4 h after a dose of colestipol.
Source: G&G 14e · p738
Related guidelines
Other Bile Acid Sequestrant drugs
Ask House about colestipol
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e, Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team