Carfilzomib
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Drug reference
conjugated estrogens
Natural estrogen mixture · Estrogen, Hormone Replacement Therapy
Natural estrogen mixtureEstrogen, Hormone Replacement Therapy
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
8 major
SEVERE in our sources
PREGNANCY
X
FDA category + note
Top interactionssee all 8 →
- CarfilzomibSevereDatabaseDDInter
- DantroleneSevereDatabaseDDInter
- HeminSevereDatabaseDDInter
- LenalidomideSevereDatabaseDDInter
Mechanism
Indications
Dysfunctional uterine bleedingHormone replacement therapy (HRT)
Dosing
- Adult
- 0.625–1.25 mg/day oral; 25 mg injection (for dysfunctional uterine bleeding); typically 0.625 mg/day dose (equivalent to ethinylestradiol 10 μg) either cyclically (3 weeks treatment 1 week gap) or continuously, but there is a trend now to use lower doses (0.3–0.45 mg/day).
Pharmacokinetics
Metabolism
undergo partial presystemic metabolism
Pregnancy & lactation
Pregnancy
X
Drug interactions
Dantrolene
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Hemin
Severe
Database
Clinical effect not specified
Source: DDInter
Lenalidomide
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Paritaprevir
Severe
Database
Clinical effect not specified
Source: DDInter
Pomalidomide
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Thalidomide
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Tranexamic Acid
Severe
Database
Clinical effect not specified
Source: DDInter
4 additional low-confidence interactions hidden — those rows lack a documented mechanism or management plan in our sources.
Related guidelines
Ask House about conjugated estrogens
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Sources: KD Tripathi 7e·Verified: 2026-05-10 · House clinical team