Adalimumab
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Drug reference
corticotropin
Pituitary hormone · Hormone
Pituitary hormoneHormone
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
- AdalimumabSevereDatabaseDDInter
- AmiodaroneSevereDatabaseDDInter
- BaricitinibSevereDatabaseDDInter
- BupropionSevereDatabaseDDInter
Mechanism
ACTH stimulates the synthesis and release of adrenocortical hormones by increasing de novo biosynthesis (steroid hormones are hydrophobic and thus cannot be stored). ACTH binding to MC2R activates the Gs–adenylyl cyclase–cyclic AMP–PKA pathway. Cyclic AMP is the second messenger for most effects of ACTH on steroidogenesis.
Indications
infantile spasmsdiagnostic assessment of adrenal cortex function
Pharmacokinetics
Half-life
about 15 min
Side effects
Serious
- acute retention of salt and water
- virilization
- hypersensitivity reactions
Drug interactions
Amiodarone
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Baricitinib
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Bupropion
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Certolizumab
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Cladribine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Desirudin
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Etanercept
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Fingolimod
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Golimumab
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Infliximab
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Leflunomide
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
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Ask House about corticotropin
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team