Drug reference
cortisone
Glucocorticoid (prodrug) · Adrenal corticosteroid
Glucocorticoid (prodrug)Adrenal corticosteroid
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
—
none in our sources
PREGNANCY
—
not curated
Mechanism
An inactive prodrug that must be enzymatically reduced to the corresponding 11β-hydroxy derivative (cortisol) by 11β-HSD1 to be biologically active.
Indications
chronic adrenal insufficiency
Dosing
- Adult
- Chronic adrenal insufficiency: 25-37.5 mg/day.
Pharmacokinetics
Duration
short (8–12 h)
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Textbook-sourced·Sources: Goodman & Gilman 14e·Updated: 2026-05-10