Drug reference
cosyntropin
Synthetic ACTH analog · Diagnostic agent
Synthetic ACTH analogDiagnostic agent
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
—
none in our sources
PREGNANCY
—
not curated
Mechanism
A synthetic peptide that corresponds to residues 1–24 of human ACTH. It maximally stimulates adrenocortical steroidogenesis.
Indications
testing the integrity of the HPA axisdiagnostic during adrenal venous sampling to distinguish between unilateral and bilateral aldosterone secretion in primary aldosteronism
Related guidelines
Acute jaundice — adult primary care
MOHFW · Gastroenterology · 2021
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ESC · Cardiology · 2026
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ADA · Endocrinology · 2025
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NICE · Neurology · 2021
Primary prevention of cardiovascular disease
AHA · Cardiology · 2019
Ask House about cosyntropin
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Sources: Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team