Abarelix
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Drug reference
Crizotinib
Tyrosine Kinase Inhibitor · Antineoplastic
Tyrosine Kinase InhibitorAntineoplasticATC null
CDSCO approvedSchedule H
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
Manufacturer advises avoid unless potential
FDA category + note
Top interactionssee all 12 →
- AbarelixSevereDatabaseDDInter
- AbirateroneSevereDatabaseDDInter
- AcalabrutinibSevereDatabaseDDInter
- AdenosineSevereDatabaseDDInter
Mechanism
Crizotinib is a first-generation inhibitor of anaplastic lymphoma kinase (ALK).
Indications
ALK-positive advanced non-small cell lung cancerlung NSCLC (ALK translocation)locally advanced or metastatic NSCLC harboring ROS1 or ALK gene rearrangements
Dosing
- Adult
- l INDICATIONS AND DOSE Anaplastic lymphoma kinase (ALK)-positive advanced non-small cell lung cancer previously treated with crizotinib (specialist use only) ▶ BY MOUTH Adult: Initially 90 mg once daily for 7 days, then increased to 180 mg once daily, for dose adjustments due to dose interruption or side-effects—consult product literature DOSE ADJUSTMENTS DUE TO INTERACTIONS ▶ Manufacturer advises…
- Renal adjustment
- The typical twice daily dosing is reduced to once daily in patients with severe renal impairment and a creatinine clearance below 30 mL/min.
Pharmacokinetics
Half-life
42 h (terminal)
Metabolism
CYP3A4/5 (predominantly)
Side effects
Common
nauseadiarrheavomitinghepatic toxicityrespiratory toxicityocular toxicityneuropathy
Serious
- QT prolongation
- bradycardia
Pregnancy & lactation
Pregnancy
Manufacturer advises avoid unless potential
Drug interactions
Abiraterone
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Acalabrutinib
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Adenosine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Alfentanil
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Alfuzosin
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Alimemazine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Amiodarone
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Amisulpride
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Amitriptyline
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Amoxapine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Amprenavir
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Related guidelines
Other Tyrosine Kinase Inhibitor drugs
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Textbook-sourced·Sources: Goodman & Gilman 14e, BNF·Updated: 2026-05-13