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cyclobenzaprine

5HT2 receptor antagonist (pharmacologically related to tricyclic antidepressants) · Central acting spasmolytic

5HT2 receptor antagonist (pharmacologically related to tricyclic antidepressants)Central acting spasmolytic
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
incl. contraindicated
PREGNANCY
—
not curated
Top interactionssee all 12 →
  • MoclobemideContraindicatedTextbookG&G 14e · p243
  • AlfentanilSevereDatabaseDDInter
  • AmitriptylineSevereDatabaseDDInter
  • AmoxapineSevereDatabaseDDInter

Mechanism

Acts centrally by a mechanism of action likely related to its activity as a 5HT2 receptor antagonist. It is not useful for spasms resulting from neurological conditions of central origin.

Indications

Short-term reduction of painful muscle spasms (e.g., those resulting from an acute peripheral injury)

Dosing

Adult
5 mg three times daily, scheduled or as needed (one dose at bedtime), for a duration of only 2 weeks.

Contraindications

  • Concomitant use with MAO inhibitors
  • Use with caution with inhibitors of 5HT uptake

Drug interactions

Moclobemide
Contraindicated
Textbook

N/A

Should not be given concomitantly.

Source: G&G 14e · p243

Alfentanil
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Amitriptyline
Severe
Database

Drug interaction classified as: synergy.

Source: DDInter

Amoxapine
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Benzhydrocodone
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Buprenorphine
Severe
Database

Drug interaction classified as: synergy.

Source: DDInter

Bupropion
Severe
Database

Drug interaction classified as: synergy.

Source: DDInter

Buspirone
Severe
Database

Drug interaction classified as: synergy.

Source: DDInter

Butorphanol
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Citalopram
Severe
Database

Drug interaction classified as: synergy.

Source: DDInter

Clomipramine
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Codeine
Severe
Database

Drug interaction classified as: synergy.

Source: DDInter

Related guidelines

Painful diabetic peripheral neuropathy
AAN · Neurology · 2022
Tobacco-related cancer prevention
ICMR · Oncology · 2021
Acute kidney injury
KDIGO · Nephrology · 2012
Diabetic foot — clinical management
MOHFW · Endocrinology · 2021
Hypertrophic cardiomyopathy
ESC · Cardiology · 2026

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Sources: Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team