Alcohol
Severe
Database
Increased sedation, dizziness, impaired psychomotor function, respiratory depression.
Advise patients to avoid alcohol consumption while taking cyproheptadine. Warn about impaired ability to drive or operate machinery.
Drug reference
cyproheptadine
Piperidine (H1 Antagonist) · Antiallergic, Antiserotonin, Antipruritic
Piperidine (H1 Antagonist)Antiallergic, Antiserotonin, Antipruritic
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
11 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 11 →
- AlcoholSevereDatabase
- Benzodiazepines (e.g., Alprazolam, Diazepam, Lorazepam)SevereDatabase
- DextropropoxypheneSevereDatabaseDDInter
- Monoamine Oxidase Inhibitors (maois) (e.g., Phenelzine, Selegiline)SevereDatabase
Mechanism
Not yet extracted
Indications
appetite stimulation (off label in anorectic/convalescent patients)idiopathic pruritus
Dosing
- Adult
- 4 mg oral
Side effects
Common
sedationdiminished alertnesslight headednessmotor incoordinationfatiguetendency to fall asleepappetite stimulating effectdry mouthalteration of bowel movementurinary hesitancyblurring of vision
Drug interactions
Benzodiazepines (e.g., Alprazolam, Diazepam, Lorazepam)
Severe
Database
Increased sedation, dizziness, confusion, impaired coordination, respiratory depression.
Avoid concomitant use if possible. If co-administration is necessary, use the lowest effective doses of both drugs, monitor closely for CNS depression. Educate patients about potential for severe drowsiness and impaired activities.
Dextropropoxyphene
Severe
Database
Clinical effect not specified
Source: DDInter
Monoamine Oxidase Inhibitors (maois) (e.g., Phenelzine, Selegiline)
Severe
Database
Exaggerated anticholinergic effects (severe dry mouth, blurred vision, urinary retention, constipation, tachycardia, confusion, delirium), increased CNS depression.
CONTRAINDICATED. Do not use cyproheptadine in patients receiving MAOIs or within 14 days of discontinuing MAOI therapy.
Opioids (e.g., Codeine, Tramadol, Morphine)
Severe
Database
Profound sedation, respiratory depression, hypotension, coma. Increased risk of falls in elderly.
Avoid concomitant use if possible. If co-administration is necessary, use the lowest effective doses of both drugs, monitor closely for CNS depression and respiratory status. Educate patients and caregivers about symptoms of overdose.
Potassium Chloride
Severe
Database
.
Source: DDInter
Potassium Citrate
Severe
Database
Clinical effect not specified
Source: DDInter
Sodium Oxybate
Severe
Database
Clinical effect not specified
Source: DDInter
Topiramate
Severe
Database
Clinical effect not specified
Source: DDInter
Tricyclic Antidepressants (tcas) (e.g., Amitriptyline, Imipramine)
Severe
Database
Increased risk of severe anticholinergic effects (dry mouth, blurred vision, urinary retention, constipation, tachycardia, confusion, delirium) and profound sedation.
Avoid concomitant use if possible. If co-administration is necessary, monitor closely for anticholinergic toxicity and CNS depression. Consider alternative agents.
Zonisamide
Severe
Database
Clinical effect not specified
Source: DDInter
1 additional low-confidence interaction hidden — those rows lack a documented mechanism or management plan in our sources.
Other Piperidine (H1 Antagonist) drugs
Ask House about cyproheptadine
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e, Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team