Adalimumab
Severe
Database
Drug interaction classified as: synergy.
Source: DDInter
Drug reference
deflazacort
corticosteroid · glucocorticoid, antiinflammatory, immunosuppressant
corticosteroidglucocorticoid, antiinflammatory, immunosuppressant
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
11 major
incl. contraindicated
PREGNANCY
—
not curated
Top interactionssee all 11 →
- AdalimumabSevereDatabaseDDInter
- AmprenavirSevereDatabaseDDInter
- ApalutamideSevereDatabaseDDInter
- AprepitantSevereDatabaseDDInter
Mechanism
Deflazacort penetrates cells and binds to a high affinity cytoplasmic receptor protein. This complex migrates into the nucleus and binds to glucocorticoid response elements (GRE) on chromatin, regulating protein synthesis. It is a glucocorticoid with antiinflammatory and immunosuppressive effects, lacking mineralocorticoid activity.
Indications
inflammatory disordersimmunological disorders
Dosing
- Adult
- 60–120 mg/day initially, 6–18 mg/day for maintenance.
Pharmacokinetics
Half-life
biological t½ 12–36 hours
Contraindications
- peptic ulcer
- diabetes mellitus
- hypertension
- viral infections
- fungal infections
- tuberculosis
- other infections
- osteoporosis
- herpes simplex keratitis
- psychosis
- epilepsy
- congestive heart failure
- renal failure
Side effects
Serious
- less growth retardation in children
Drug interactions
Amprenavir
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Apalutamide
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Aprepitant
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Atazanavir
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Baricitinib
Severe
Database
Drug interaction classified as: others
Source: DDInter
Bempedoic Acid
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Berotralstat
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Boceprevir
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Bosentan
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Brexucabtagene Autoleucel
Severe
Database
Drug interaction classified as: others
Source: DDInter
1 additional unreviewed or low-confidence interaction hidden because their provenance or source detail is insufficient.
Related guidelines
Hypertensive disorders of pregnancy
FOGSI · Obstetrics & Gynaecology · 2019
Inflammatory bowel disease
OTHER · Gastroenterology · 2015
Substance use disorders
NIMHANS · Psychiatry · 2022
Preventive care in inflammatory bowel disease
ACG · Gastroenterology · 2025
Primary headache disorders
NICE · Neurology · 2021
Ask House about deflazacort
Continue into a citation-backed clinical answer with the drug context already attached.
Textbook-sourced·Sources: KD Tripathi 7e·Updated: 2026-05-10