Drug reference
des-ciclesonide
Active metabolite of ciclesonide · Anti-inflammatory
Active metabolite of ciclesonideAnti-inflammatory
CDSCO approved
EXCRETION
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not curated
INTERACTIONS
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none in our sources
PREGNANCY
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not curated
Mechanism
Des-ciclesonide is the active metabolite of ciclesonide. Corticosteroids enter target cells and bind to GRs in the cytoplasm. The steroid-GR complex moves into the nucleus, influencing gene transcription to suppress inflammation. This involves increasing the transcription of anti-inflammatory genes and suppressing inflammatory genes.
Related guidelines
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Textbook-sourced·Sources: Goodman & Gilman 14e·Updated: 2026-05-10