Alfentanil
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Drug reference
desvenlafaxine
Serotonin-Norepinephrine Reuptake Inhibitor · Antidepressant, Anxiolytic
Serotonin-Norepinephrine Reuptake InhibitorAntidepressant, Anxiolytic
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
11 major
incl. contraindicated
PREGNANCY
—
not curated
Top interactionssee all 11 →
- AlfentanilSevereDatabaseDDInter
- AlmotriptanSevereDatabaseDDInter
- AmitriptylineSevereDatabaseDDInter
- AmoxapineSevereDatabaseDDInter
Mechanism
Desvenlafaxine inhibits both the neuronal serotonin/5HT transporter (SERT) and the neuronal NE transporter (NET), enhancing both serotonergic and noradrenergic neurotransmission. Initial inhibition of SERT activates 5HT1A and 5HT1D autoreceptors, decreasing transmission until desensitization. Repeated treatment reduces expression of SERT or NET, leading to increased neurotransmitter clearance.
Indications
depressionanxiety disorderspain (off-label)
Pharmacokinetics
Half-life
11 hours
Bioavailability
b
Protein binding
ODV: 30 ± 12%
Metabolism
hepatic and renal excretion
Excretion
ODV: 29 ± 7%
Side effects
Common
nauseaconstipationinsomniaheadachessexual dysfunction
Serious
- discontinuation syndrome (most intense)
- serotonin syndrome (with MAOIs)
- suicidal thoughts or behavior (black-box warning)
Drug interactions
Almotriptan
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Amitriptyline
Severe
Database
Drug interaction classified as: synergy.
Source: DDInter
Amoxapine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Amphetamine
Severe
Database
Drug interaction classified as: synergy.
Source: DDInter
Benzphetamine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Bupropion
Severe
Database
Drug interaction classified as: synergy.
Source: DDInter
Buspirone
Severe
Database
Drug interaction classified as: synergy.
Source: DDInter
Citalopram
Severe
Database
Drug interaction classified as: synergy.
Source: DDInter
Clomipramine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Cyclobenzaprine
Severe
Database
.
Source: DDInter
1 additional unreviewed or low-confidence interaction hidden because their provenance or source detail is insufficient.
Related guidelines
Other Serotonin-Norepinephrine Reuptake Inhibitor drugs
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Textbook-sourced·Sources: Goodman & Gilman 14e·Updated: 2026-05-10