Xipamide
Contraindicated
Textbook
Fatal ventricular arrhythmias.
Avoid coadministration or ensure strict potassium management.
Source: G&G 14e · p567
Drug reference
dofetilide
K+ Channel Blocker (Class III) · Antiarrhythmic
K+ Channel Blocker (Class III)AntiarrhythmicATC C01BD07
CDSCO approvedATC C01BD07
EXCRETION
—
not curated
INTERACTIONS
12 major
incl. contraindicated
PREGNANCY
—
not curated
Top interactionssee all 12 →
- XipamideContraindicatedTextbookG&G 14e · p567
- AzolesSevereTextbookHarrison 22e · p1742
- AbarelixSevereDatabaseDDInter
- AbirateroneSevereDatabaseDDInter
Mechanism
Dofetilide prolongs action potentials and the QT interval by potently blocking the IKr channel. Increased late Na+ current, likely due to inhibition of phosphoinositide 3-kinase, may also contribute. The drug has virtually no extracardiac pharmacological effects.
Indications
Maintaining sinus rhythm in patients with atrial fibrillationConversion of atrial fibrillation (AF) to sinus rhythmConversion of atrial flutter (AFl) to sinus rhythmMaintenance of sinus rhythm after conversion
Dosing
- Adult
- 0.25–0.5 mg q12h
- Renal adjustment
- Decreases in dosage based on creatinine clearance are required to minimize the risk of torsades de pointes.
Pharmacokinetics
Half-life
7–10 h
Bioavailability
>80%
Protein binding
Not specified
Metabolism
Minor hepatic metabolism
Excretion
Mainly excreted unchanged in urine
Contraindications
- Advanced renal failure
- Inhibitors of renal cation transport
- Prolonged QT interval
Side effects
Common
Few side effects
Serious
- Torsades de pointes (1% to 3% in clinical trials)
- Torsades de pointes (in some recipients)
Drug interactions
Azoles
Severe
Textbook
Increased plasma levels of dofetilide.
Source: Harrison 22e · p1742
Abarelix
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Abiraterone
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Acetazolamide
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Adenosine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Alfuzosin
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Alimemazine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Amiodarone
Severe
Database
Drug interaction classified as: synergy.
Source: DDInter
Amisulpride
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Amitriptyline
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Amoxapine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Related guidelines
Other K+ Channel Blocker (Class III) drugs
Ask House about dofetilide
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e, Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team