doxylamine succinate

Doxylamine succinate is a histamine H1 antagonist. When combined with pyridoxine, it effectively treats mild-to-moderate nausea and vomiting of pregnancy. Its exact antiemetic mechanism for pregnancy is not fully elucidated but involves antihistaminic properties.

Adult

Initially, two delayed-release tablets (doxylamine 20 mg, pyridoxine 20 mg) at bedtime. May be increased to four tablets per day as needed (one morning, one afternoon, two bedtime).