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ebastine

Second generation H1 antihistaminic · Antiallergic, Antihistaminic

Second generation H1 antihistaminicAntiallergic, Antihistaminic
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
  • AprepitantSevereTextbookKDT 7e
  • CiprofloxacinSevereTextbookKDT 7e
  • CobicistatSevereTextbookKDT 7e
  • ImatinibSevereTextbookKDT 7e

Mechanism

H1 antagonism.

Indications

nasal allergiesskin allergies

Dosing

Adult
10 mg oral

Pharmacokinetics

Half-life
active metabolite carbastine has t½ of 10–16 hr
Metabolism
rapidly converted to the active metabolite carbastine

Side effects

Common
nonsedating
Serious
  • prolongs Q-Tc interval (animal studies)
  • arrhythmogenic potential

Drug interactions

Aprepitant
Severe
Textbook

Increased risk of arrhythmogenic potential.

Exercise caution with coadministration.

Source: KDT 7e

Ciprofloxacin
Severe
Textbook

Increased risk of arrhythmogenic potential.

Exercise caution with coadministration.

Source: KDT 7e

Cobicistat
Severe
Textbook

Increased risk of arrhythmogenic potential.

Exercise caution with coadministration.

Source: KDT 7e

Imatinib
Severe
Textbook

Increased risk of arrhythmogenic potential.

Exercise caution with coadministration.

Source: KDT 7e

Indinavir
Severe
Textbook

Increased risk of arrhythmogenic potential.

Exercise caution with coadministration.

Source: KDT 7e

Lopinavir
Severe
Textbook

Increased risk of arrhythmogenic potential.

Exercise caution with coadministration.

Source: KDT 7e

Nefazodone
Severe
Textbook

Increased risk of arrhythmogenic potential.

Exercise caution with coadministration.

Source: KDT 7e

Nelfinavir
Severe
Textbook

Increased risk of arrhythmogenic potential.

Exercise caution with coadministration.

Source: KDT 7e

Posaconazole
Severe
Textbook

Increased risk of arrhythmogenic potential.

Exercise caution with coadministration.

Source: KDT 7e

Saquinavir
Severe
Textbook

Increased risk of arrhythmogenic potential.

Exercise caution with coadministration.

Source: KDT 7e

Telithromycin
Severe
Textbook

Increased risk of arrhythmogenic potential.

Exercise caution with coadministration.

Source: KDT 7e

Voriconazole
Severe
Textbook

Increased risk of arrhythmogenic potential.

Exercise caution with coadministration.

Source: KDT 7e

Related guidelines

Stroke and TIA — secondary prevention
AHA · Neurology · 2021
Dyslipidaemia management
ICMR · Cardiology · 2023
Glomerular diseases
KDIGO · Nephrology · 2021
Dyslipidaemia management
ESC · Cardiology · 2019
Dyslipidaemia management
AHA · Cardiology · 2018

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Sources: KD Tripathi 7e·Verified: 2026-05-10 · House clinical team