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Drug reference

elagolix

Oral GnRH Receptor Antagonist · Hormone Antagonist

Oral GnRH Receptor AntagonistHormone Antagonist
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
  • AtazanavirSevereDatabaseDDInter
  • BenzhydrocodoneSevereDatabaseDDInter
  • BerotralstatSevereDatabaseDDInter
  • BoceprevirSevereDatabaseDDInter

Mechanism

Elagolix is an oral GnRH receptor antagonist that suppresses gonadotropin secretion, leading to a hypoestrogenic state that improves endometriosis symptoms.

Indications

endometriosis (improving dysmenorrhea and pelvic pain)

Side effects

Common
hot flashesincreased serum lipids
Serious
  • reduction in bone mineral density

Drug interactions

Atazanavir
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Benzhydrocodone
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Berotralstat
Severe
Database

Drug interaction classified as: absorption

Source: DDInter

Boceprevir
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Butorphanol
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Ceritinib
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Clarithromycin
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Cobicistat
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Conivaptan
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Cyclosporine
Severe
Database

Clinical effect not specified

Source: DDInter

Delavirdine
Severe
Database

Clinical effect not specified

Source: DDInter

Edoxaban
Severe
Database

Clinical effect not specified

Source: DDInter

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Textbook-sourced·Sources: Goodman & Gilman 14e·Updated: 2026-05-10