Amiodarone
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Drug reference
entrectinib
TRK inhibitor, kinase inhibitor · antineoplastic, targeted therapy
TRK inhibitor, kinase inhibitorantineoplastic, targeted therapy
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
D
FDA category + note
Top interactionssee all 12 →
- AmiodaroneSevereDatabaseDDInter
- AmisulprideSevereDatabaseDDInter
- AmprenavirSevereDatabaseDDInter
- AnagrelideSevereDatabaseDDInter
Mechanism
Specific small-molecule inhibitor of NTRK fusion genes.
Indications
systemic therapy of follicular cell-derived thyroid cancers with NTRK fusion gene driver mutationsany cancers with TRK gene fusions without resistance mutationmetastatic NSCLC positive for ROS1
Pharmacokinetics
Half-life
approximately 20 h
Metabolism
CYP3A
Side effects
Serious
- increased risk for congestive heart failure
- cognitive impairment
- hepatotoxicity
- prolongation of QT intervals
Pregnancy & lactation
Pregnancy
D
Drug interactions
Amisulpride
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Amprenavir
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Anagrelide
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Apalutamide
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Aprepitant
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Arsenic Trioxide
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Atazanavir
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Bedaquiline
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Bepridil
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Berotralstat
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Boceprevir
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Related guidelines
Hypothyroidism in adults
ITS · Endocrinology · 2021
Antimicrobial resistance — clinical roadmap
MOHFW · Infectious Diseases · 2012
Blood transfusion in obstetrics and gynaecology
FOGSI · Obstetrics & Gynaecology · 2024
Hypothyroidism in adults
ENDOCRINE_SOCIETY · Endocrinology · 2014
Systemic lupus erythematosus
EULAR · Rheumatology · 2023
Ask House about entrectinib
Continue into a citation-backed clinical answer with the drug context already attached.
Textbook-sourced·Sources: Goodman & Gilman 14e·Updated: 2026-05-10