Drug reference

Estramustine phosphate

Alkylating Agent · Antineoplastic agent

Alkylating AgentAntineoplastic agent

CDSCO approvedSchedule H

EXCRETION

—

not curated

INTERACTIONS

—

none in our sources

PREGNANCY

and reproductive function in Cytotoxic drugs

FDA category + note

Mechanism

Estramustine phosphate is a combination of an estrogen and chlormethine, which is an alkylating agent. It exerts an antimitotic effect by damaging DNA and interfering with cell replication. Additionally, it has a hormonal effect by reducing testosterone concentrations.

Indications

Prostate cancer

Dosing

Adult: adults for the treatment of recurrent glioblastoma multiforme as an adjunct to surgery. Carmustine implants are also licensed for high-grade malignant glioma as adjunctive treatment to surgery and radiotherapy. Estramustine phosphate p. 946 is a combination of an oestrogen and chlormethine used predominantly in prostate cancer.…