Aromatase Inhibitors
Moderate
Textbook
Reduces the efficacy of aromatase inhibitors.
Avoid coadministration.
Source: G&G 14e · p1447
Drug reference
estrogen
Hormone · Antiresorptive agent
HormoneAntiresorptive agent
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
—
none in our sources
PREGNANCY
—
not curated
Mechanism
Preserves bone and protects against osteoporotic fracture after menopause. It inhibits osteoclast-mediated bone loss.
Indications
prevention of osteoporosisshort-term relief of vasomotor symptoms associated with menopause
Side effects
Serious
- increased risks of heart disease
- breast cancer
Drug interactions
Levothyroxine
Moderate
Textbook
Increased levothyroxine dosage requirements.
May require increased levothyroxine dosage.
Source: G&G 14e
Related guidelines
Ask House about estrogen
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team