Drug reference

Ethinylestradiol, Etonogestrel

Progestogen · Contraception

Also known as NuvaRing, SyreniRing

ProgestogenContraception

CDSCO approvedSchedule H

EXCRETION

—

not curated

INTERACTIONS

—

none in our sources

PREGNANCY

—

not curated

Mechanism

Combination hormonal contraceptives prevent ovulation by suppressing LH and FSH levels, thereby inhibiting the mid-cycle LH surge and diminishing endogenous steroid levels. This synergistic action of estrogen and progestin consistently suppresses ovulation. Progestin also plays a major role by diminishing the frequency of GnRH pulses, which are essential for LH pulse frequency and ovulation.

Indications

Contraception

Dosing

Adult: Insert one vaginal ring and leave in place for 3 consecutive weeks, followed by a 7-day ring-free interval. A new ring is inserted after this 7-day interval. If the ring is expelled for more than 3 hours during week 1 or 2, rinse and reinsert; use additional barrier precautions for 7 days.…

Pharmacokinetics

Onset

Full contraceptive protection may take 7 days if initiated later than day 5 of the menstrual cycle, or after re-insertion following an extended ring-free interval or expulsion.

Duration

The ring is used for 3 weeks, providing continuous hormone release. Contraceptive protection can extend up to 4 weeks of continuous use.