Acalabrutinib
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Drug reference
fedratinib
JAK2 inhibitor · Immunosuppressant
JAK2 inhibitorImmunosuppressant
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
D
FDA category + note
Top interactionssee all 12 →
- AcalabrutinibSevereDatabaseDDInter
- AlfentanilSevereDatabaseDDInter
- AmprenavirSevereDatabaseDDInter
- ApalutamideSevereDatabaseDDInter
Mechanism
Not yet extracted
Indications
myelofibrosisrheumatoid arthritispsoriatic arthritisulcerative colitispolycythemia veragvhdankylosing spondyloarthritisallergic dermatitisatopic dermatitis
Pharmacokinetics
Half-life
114 h (terminal elimination)
Metabolism
CYP3A
Contraindications
- patients at high risk of pulmonary embolism
- nonuse during breastfeeding
- concurrent use of live vaccines
Side effects
Common
thrombocytopeniaanemianeutropeniaincreased risk of infections (upper respiratory, sinus, common cold, hepatitis c virus)diarrheanausea
Serious
- increased risk of serious bacterial, fungal, viral, and opportunistic infections leading to hospitalization or death
- higher rate of all-cause mortality, including sudden cardiovascular death
- higher rate of certain cancers
- higher rate of thrombosis, cardiovascular death, myocardial infarction, and stroke
- serious and fatal encephalopathy
- anemia
- thrombocytopenia
- GI toxicity
- hepatic toxicity
Pregnancy & lactation
Pregnancy
D
Drug interactions
Alfentanil
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Amprenavir
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Apalutamide
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Ardeparin
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Argatroban
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Atazanavir
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Avanafil
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Avapritinib
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Benzhydrocodone
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Betrixaban
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Bivalirudin
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Related guidelines
Other JAK2 inhibitor drugs
Ask House about fedratinib
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team