Moclobemide
Severe
Textbook
Exaggerated hypertensive response.
Fenoldopam should be avoided or used at much lower doses if the patient has received a MAO inhibitor.
Source: G&G 14e · p259
Drug reference
fenoldopam
D1 receptor agonist, α2 adrenergic receptor agonist · Antihypertensive
D1 receptor agonist, α2 adrenergic receptor agonistAntihypertensiveATC C01CA16
CDSCO approvedATC C01CA16
EXCRETION
—
not curated
INTERACTIONS
10 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 10 →
- MoclobemideSevereTextbookG&G 14e · p259
- AmiodaroneSevereDatabaseDDInter
- Arsenic TrioxideSevereDatabaseDDInter
- DofetilideSevereDatabaseDDInter
Mechanism
Fenoldopam is an agonist for peripheral D1 receptors, leading to vasodilation. It also binds with moderate affinity to α2 adrenergic receptors. It dilates coronary arteries, afferent and efferent arterioles in the kidney, and mesenteric arteries.
Indications
control of severe hypertension (e.g., malignant hypertension with end-organ damage) in hospitalized patientsHypertensive emergencies
Dosing
- Adult
- 0.01 to 1.6 μg/kg per min (IV infusion)
Pharmacokinetics
Half-life
about 10 min (IV)
Bioavailability
less than 6% (oral) due to extensive first-pass metabolism
Metabolism
extensive first-pass formation of sulfate, methyl, and glucuronide conjugates
Side effects
Common
headacheflushingdizzinesstachycardiabradycardia
Drug interactions
Amiodarone
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Arsenic Trioxide
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Dofetilide
Severe
Database
Clinical effect not specified
Source: DDInter
Dronedarone
Severe
Database
Clinical effect not specified
Source: DDInter
Droperidol
Severe
Database
Clinical effect not specified
Source: DDInter
Levacetylmethadol
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Pimozide
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Tizanidine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Ziprasidone
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
2 additional low-confidence interactions hidden — those rows lack a documented mechanism or management plan in our sources.
Related guidelines
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Sources: KD Tripathi 7e, Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team