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floxuridine

pyrimidine analogue, antimetabolite · anticancer

pyrimidine analogue, antimetaboliteanticancer
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
  • AdalimumabSevereDatabaseDDInter
  • BaricitinibSevereDatabaseDDInter
  • CertolizumabSevereDatabaseDDInter
  • CladribineSevereDatabaseDDInter

Mechanism

Fluorodeoxyuridine (FUdR) is converted directly to FdUMP by thymidine kinase. FdUMP inhibits thymidylate synthase, blocking the synthesis of deoxythymidine triphosphate (dTTP).

Indications

metastatic carcinoma of the colon (primarily by continuous infusion into the hepatic artery)hepatic metastases (following resection, by intrahepatic arterial infusion)

Pharmacokinetics

Onset
not specified
Peak effect
not specified
Protein binding
not specified
Metabolism
converted directly to FdUMP by thymidine kinase

Side effects

Common
minimal systemic toxicity (with intrahepatic arterial infusion)stomatitisdiarrhea
Serious
  • biliary sclerosis (significant risk if intrahepatic arterial infusion is used for multiple cycles)
  • bone marrow suppression (maximal effects at days 7-14)
  • gut toxicity (maximal effects at days 7-14)

Drug interactions

Adalimumab
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Baricitinib
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Certolizumab
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Cladribine
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Clozapine
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Deferiprone
Severe
Database

Clinical effect not specified

Source: DDInter

Etanercept
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Fingolimod
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Golimumab
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Infliximab
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Leflunomide
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Measles Virus Vaccine Live Attenuated
Severe
Database

Drug interaction classified as: others

Source: DDInter

Related guidelines

Acute liver failure
ICMR · Gastroenterology · 2022
Glucose monitoring in diabetes
RSSDI · Endocrinology · 2024
Acute jaundice — adult primary care
MOHFW · Gastroenterology · 2021

Other pyrimidine analogue, antimetabolite drugs

fluorouracil
0 brands

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Sources: Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team