Drug reference

fomivirsen

Antisense oligonucleotide · Antiviral (Anti-CMV)

Antisense oligonucleotideAntiviral (Anti-CMV)

CDSCO approved

EXCRETION

—

not curated

INTERACTIONS

—

none in our sources

PREGNANCY

—

not curated

Mechanism

Fomivirsen is a 21-base phosphorothioate oligonucleotide that provides antisense therapy. It is complementary to the mRNA sequence for the major immediate-early transcriptional region of CMV and inhibits CMV replication through sequence-specific and nonspecific mechanisms, including inhibition of virus binding to cells.

Indications

CMV retinitis (for patients intolerant of or unresponsive to other therapies, and in HIV-infected patients with refractory, sight-threatening CMV retinitis)CMV retinitis (injected into vitreous humor)