Tizanidine
Severe
Database
Clinical effect not specified
Source: DDInter
Drug reference
guanabenz
α2 adrenergic receptor agonist · Antihypertensive
α2 adrenergic receptor agonistAntihypertensiveATC C02AC06
CDSCO approvedATC C02AC06
EXCRETION
—
not curated
INTERACTIONS
1 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactions
- TizanidineSevereDatabaseDDInter
Mechanism
Guanabenz decreases blood pressure by a mechanism similar to clonidine and guanfacine, acting as a centrally acting α2 agonist.
Indications
hypertension
Pharmacokinetics
Half-life
4 to 6 h
Metabolism
extensively metabolized by the liver
Contraindications
- abrupt discontinuation (withdrawal syndrome)
Side effects
Common
dry mouthsedation
Drug interactions
11 additional low-confidence interactions hidden — those rows lack a documented mechanism or management plan in our sources.
Related guidelines
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Sources: Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team