Drug reference

halofantrine

Phenanthrene methanol · Antimalarial

Phenanthrene methanolAntimalarial

CDSCO approved

EXCRETION

—

not curated

INTERACTIONS

12 major

incl. contraindicated

PREGNANCY

—

not curated

Top interactionssee all 12 →

AmisulprideContraindicatedDatabaseDDInter
Agents That Prolong Qtc IntervalSevereTextbookHarrison 22e · p1741
AbirateroneSevereDatabaseDDInter
AdenosineSevereDatabaseDDInter

Mechanism

Not yet extracted

Indications

Multiresistant falciparum malaria (when no other effective alternative is available, not approved in India)

Pharmacokinetics

Protein binding

Low and erratic oral absorption

Contraindications

Patients on QTc prolonging drugs

Side effects

Serious

Prolongation of QTc interval
Serious ventricular arrhythmia (some fatal)

Drug interactions

Amisulpride

Contraindicated

Database

Increased risk of Torsades de Pointes (TdP) and other ventricular arrhythmias

Concomitant use is contraindicated. Avoid combination.

Source: DDInter

Agents That Prolong Qtc Interval

Severe

Textbook

Increased risk of ECG disturbances, specifically QTc prolongation, which can lead to serious arrhythmias.

Not specified in the text, but likely avoidance or close cardiac monitoring.

Source: Harrison 22e · p1741

Abiraterone

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Adenosine

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Alfuzosin

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Amiodarone

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Amitriptyline

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Amoxapine

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Amprenavir

Severe

Database

Drug interaction classified as: metabolism

Source: DDInter

Anagrelide

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Apalutamide

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Apomorphine

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Related guidelines

Malaria treatment

ICMR · Infectious Disease · 2021

Type 2 diabetes in adults

RSSDI · Endocrinology · 2022

Hypertension in adults

ICMR · Cardiology · 2019

Type 2 diabetes in adults

ICMR · Endocrinology · 2022

Antimicrobial resistance — clinical roadmap

MOHFW · Infectious Diseases · 2012

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Sources: KD Tripathi 7e·Verified: 2026-05-10 · House clinical team