Drug reference

hi-6

Cholinesterase reactivator; Bis-quaternary aldoxime · Antidote (for organophosphate poisoning)

Cholinesterase reactivator; Bis-quaternary aldoximeAntidote (for organophosphate poisoning)

CDSCO approved

EXCRETION

—

not curated

INTERACTIONS

—

none in our sources

PREGNANCY

—

not curated

Mechanism

HI-6 is a bis-quaternary aldoxime that acts as a potent reactivator for organophosphate-inhibited acetylcholinesterase (AChE). It nucleophilically attacks the conjugated phosphorus of the inhibited enzyme, forming a phospho-oxime and regenerating active AChE.

Pharmacokinetics

Protein binding

Does not cross the blood-brain barrier, limiting effectiveness to peripheral nervous system sites.

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Sources: Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team