Drug reference

icosapent ethyl

Omega-3 Fatty Acid Ethyl Ester · Antihyperlipidemic

Omega-3 Fatty Acid Ethyl EsterAntihyperlipidemic

CDSCO approved

EXCRETION

—

not curated

INTERACTIONS

—

none in our sources

PREGNANCY

—

not curated

Mechanism

Icosapent ethyl is a highly purified ethyl ester of eicosapentaenoic acid (EPA) that reduces VLDL triglycerides. Its precise mechanism involves various pathways including inhibition of triglyceride synthesis and enhancement of fatty acid oxidation in the liver, leading to reduced VLDL particle secretion.

Indications

Adjunct to diet for severe hypertriglyceridemia (triglycerides ≥500 mg/dL)Adjunct to maximally tolerated statin therapy to reduce risk of cardiovascular events in adults with triglyceride levels ≥150 mg/dL, with diabetes and ASCVD or other cardiovascular disease risk factors and well-controlled LDL-C.