Adalimumab
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Drug reference
Idarubicin
Anthracycline · Antineoplastic agent
Also known as Idarubicin hydrochloride
AnthracyclineAntineoplastic agent
CDSCO approvedSchedule H
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
and reproductive function in Cytotoxic drugs
FDA category + note
Top interactionssee all 12 →
- AdalimumabSevereDatabaseDDInter
- AmiodaroneSevereDatabaseDDInter
- AmisulprideSevereDatabaseDDInter
- AnagrelideSevereDatabaseDDInter
Mechanism
Idarubicin is an anthracycline antibiotic that intercalates with DNA, directly affecting transcription and replication. A more important mechanism involves forming a tripartite complex with topoisomerase II and DNA, thereby inhibiting topoisomerase II activity. These agents also possess the potential for generating free radicals.
Indications
Haematological malignanciesAcute leukemiasAcute myeloid leukemia (AML) (in combination with Ara-C)Acute lymphocytic leukemia (ALL)
Dosing
- Adult
- cyclophosphamide by the intravenous route at a high dose (e.g. more than 2 g) or in those who experienced urothelial toxicity when given cyclophosphamide previously. Anthracyclines and other cytotoxic antibiotics Drugs in this group are widely used. Many cytotoxic antibiotics act as radiomimetics and simultaneous use of radiotherapy should be avoided because it may markedly increased toxicity.…
Pharmacokinetics
Half-life
15 h (Idarubicin); 40 h (Idarubicinol, active metabolite)
Protein binding
Rapidly enters the heart, kidneys, lungs, liver, and spleen; does not cross the blood-brain barrier.
Metabolism
Converted to an active alcohol intermediate (idarubicinol).
Excretion
Cleared by a complex pattern of hepatic metabolism and biliary excretion.
Side effects
Common
Bone marrow depressionStomatitisAlopeciaGastrointestinal disturbancesRashCardiac toxicity (acute or chronic)
Serious
- Cardiomyopathy (dose-related, often irreversible)
- Cardiac toxicity (less cardiotoxicity than other anthracyclines)
Pregnancy & lactation
Pregnancy
and reproductive function in Cytotoxic drugs
Drug interactions
Amiodarone
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Amisulpride
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Anagrelide
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Arsenic Trioxide
Severe
Database
Drug interaction classified as: synergy.
Source: DDInter
Baricitinib
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Bedaquiline
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Bepridil
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Cabozantinib
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Ceritinib
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Certolizumab
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Chloroquine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Related guidelines
Other Anthracycline drugs
Ask House about Idarubicin
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Goodman & Gilman 14e, Harrison 22e, BNF·Verified: 2026-05-13 · House clinical team