Cinoxacin
Severe
Database
Drug interaction classified as: antagonism
Source: DDInter
Drug reference
insulin degludec
Long-acting insulin analogue · Antidiabetic agent
Long-acting insulin analogueAntidiabetic agent
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
- CinoxacinSevereDatabaseDDInter
- CiprofloxacinSevereDatabaseDDInter
- DelafloxacinSevereDatabaseDDInter
- EnoxacinSevereDatabaseDDInter
Mechanism
Insulin degludec is a modified insulin with one amino acid deleted (threonine at B30) and conjugated to hexadecanedioic acid. When injected subcutaneously, it forms multihexameric complexes and binds to albumin, which together slow its absorption and extend its action for prolonged basal insulin coverage.
Indications
Provide basal insulin in type 1 diabetesProvide basal insulin in type 2 diabetes
Pharmacokinetics
Onset
1-9 h
Peak effect
0h (little peak activity at steady state)
Duration
42 h
Side effects
Common
Hypoglycemia
Drug interactions
Ciprofloxacin
Severe
Database
Drug interaction classified as: antagonism
Source: DDInter
Delafloxacin
Severe
Database
Clinical effect not specified
Source: DDInter
Enoxacin
Severe
Database
Clinical effect not specified
Source: DDInter
Gatifloxacin
Severe
Database
Clinical effect not specified
Source: DDInter
Gemifloxacin
Severe
Database
Clinical effect not specified
Source: DDInter
Grepafloxacin
Severe
Database
Clinical effect not specified
Source: DDInter
Levofloxacin
Severe
Database
Clinical effect not specified
Source: DDInter
Lomefloxacin
Severe
Database
Clinical effect not specified
Source: DDInter
Moxifloxacin
Severe
Database
Clinical effect not specified
Source: DDInter
Nalidixic Acid
Severe
Database
Clinical effect not specified
Source: DDInter
Norfloxacin
Severe
Database
Clinical effect not specified
Source: DDInter
Related guidelines
Fluid and electrolyte management in diabetes
RSSDI · Endocrinology · 2025
Diabetes management during Ramadan
ADA · Endocrinology · 2025
Glucose monitoring in diabetes
RSSDI · Endocrinology · 2024
Gestational diabetes mellitus
FOGSI · Obstetrics & Gynaecology · 2023
Type 2 diabetes in adults
RSSDI · Endocrinology · 2022
Ask House about insulin degludec
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team