Cinoxacin
Severe
Database
Drug interaction classified as: antagonism
Source: DDInter
Drug reference
Insulin Lispro
Rapid-acting insulin analogue · Antidiabetic
START
SC 0–15 min before meals; individualised by carb ratio/correction factor
TYPICAL MAX
No fixed ceiling — titrate to prandial glucose
STOP IF
Hypoglycaemia (treat first)
WATCH
Pre/post-meal glucose, hypoglycaemia (esp. renal impairment, missed meals), injection technique, correct strength
CDSCO approvedATC A10AB04
KDIGO 2024 + manufacturer label
- ONSET
- 15min · prandial onset
- PEAK
- 1h · peak
- t½
- 1h · effect t½
- DURATION
- 4h · prandial duration
EXCRETION
Enzymatic degradation (hepatic/renal)
route + CYP
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
Acceptable in pregnancy when prandial insulin needed — commonly used; titrate to targets
FDA category + note
Top interactionssee all 12 →
- CinoxacinSevereDatabaseDDInter
- CiprofloxacinSevereDatabaseDDInter
- DelafloxacinSevereDatabaseDDInter
- EnoxacinSevereDatabaseDDInter
Available in India
7 branded formulations and 8 fixed-dose combinations. Look up specific brands in the Drugs workspace.
Mechanism
Recombinant insulin analogue (Lys-B28, Pro-B29 reversal) reducing self-association → faster SC absorption and rapid, short prandial insulin-receptor agonism; mimics physiological mealtime insulin.
Indications
Type 1 and type 2 diabetes mellitus — prandial (bolus) coverageInsulin pump (CSII) therapy
Dosing
- Adult
- SC immediately before (0–15 min) or just after meals; individualised by carbohydrate counting/correction. Also CSII and (lispro) IV in specialist settings. U-100 and U-200 available.
- Pediatric
- Weight/meal-based, individualised (specialist).
- Renal adjustment
- Reduced insulin requirement in renal impairment — titrate down.
- Hepatic adjustment
- Variable requirement; titrate to glucose.
- Geriatric
- Conservative targets; hypoglycaemia risk.
- Max dose
- No fixed ceiling — titrated to prandial glucose
Pharmacokinetics
Onset
~15 min
Peak effect
~30–90 min
Duration
~3–5 h
Half-life
~1 h (SC effect)
Bioavailability
SC
Protein binding
Low
Metabolism
Hepatic/renal insulin-degrading enzyme
Excretion
Renal degradation
Contraindications
- Hypoglycaemia
- Hypersensitivity to insulin lispro/excipients
Side effects
Common
HypoglycaemiaWeight gainInjection-site lipohypertrophy/reactionsTransient visual changes on initiation
Serious
- Severe hypoglycaemia (coma/seizure)
- Severe hypokalaemia
- Severe hypersensitivity/anaphylaxis (rare)
Pregnancy & lactation
Pregnancy
Acceptable in pregnancy when prandial insulin needed — commonly used; titrate to targets
Lactation
Compatible — not orally bioavailable to infant; adjust maternal dose
Drug interactions
Ciprofloxacin
Severe
Database
Drug interaction classified as: antagonism.
Source: DDInter
Delafloxacin
Severe
Database
Clinical effect not specified
Source: DDInter
Enoxacin
Severe
Database
Clinical effect not specified
Source: DDInter
Gatifloxacin
Severe
Database
Clinical effect not specified
Source: DDInter
Gemifloxacin
Severe
Database
Clinical effect not specified
Source: DDInter
Grepafloxacin
Severe
Database
Clinical effect not specified
Source: DDInter
Levofloxacin
Severe
Database
.
Source: DDInter
Lomefloxacin
Severe
Database
Clinical effect not specified
Source: DDInter
Moxifloxacin
Severe
Database
.
Source: DDInter
Nalidixic Acid
Severe
Database
Clinical effect not specified
Source: DDInter
Norfloxacin
Severe
Database
Clinical effect not specified
Source: DDInter
Related guidelines
Gestational diabetes mellitus
FOGSI · Obstetrics & Gynaecology · 2023
Fluid and electrolyte management in diabetes
RSSDI · Endocrinology · 2025
Diabetes management during Ramadan
ADA · Endocrinology · 2025
Glucose monitoring in diabetes
RSSDI · Endocrinology · 2024
Type 2 diabetes in adults
RSSDI · Endocrinology · 2022
Other Rapid-acting insulin analogue drugs
Ask House about Insulin Lispro
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Goodman & Gilman 14e, Katzung, BNF·Verified: 2026-05-19 · House clinical team·Cockpit curated: 2026-05-19