Amprenavir
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Drug reference
istradefylline
Adenosine A2A Receptor Antagonist · Parkinson's disease treatment
Adenosine A2A Receptor AntagonistParkinson's disease treatment
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
- AmprenavirSevereDatabaseDDInter
- ApalutamideSevereDatabaseDDInter
- AtazanavirSevereDatabaseDDInter
- BoceprevirSevereDatabaseDDInter
Mechanism
Enhances D2 receptor signaling through blocking D2 receptor inhibition by the A2A receptor.
Indications
Parkinson's disease (adjunctive therapy with L-DOPA)adjunctive therapy with l-DOPA for Parkinson's diseaseAdjunctive treatment for off periods in PDMay help nonmotor symptoms such as urinary dysfunction, daytime sleepiness, and cognitive impairment
Side effects
Common
hallucinationsnauseadizziness
Drug interactions
Apalutamide
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Atazanavir
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Boceprevir
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Carbamazepine
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Ceritinib
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Clarithromycin
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Cobicistat
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Colchicine
Severe
Database
Drug interaction classified as: excretion
Source: DDInter
Conivaptan
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Delavirdine
Severe
Database
Clinical effect not specified
Source: DDInter
Enzalutamide
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Related guidelines
Coronary angiography with renal dysfunction
CSI · Cardiology · 2020
Coeliac disease
OTHER · Gastroenterology · 2016
Inflammatory bowel disease
OTHER · Gastroenterology · 2015
Chronic kidney disease — assessment and management
KDIGO · Nephrology · 2024
Gastro-oesophageal reflux disease
ISG · Gastroenterology · 2022
Ask House about istradefylline
Continue into a citation-backed clinical answer with the drug context already attached.
Textbook-sourced·Sources: Goodman & Gilman 14e·Updated: 2026-05-10