Adalimumab
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Drug reference
Ixazomib
Proteasome Inhibitor · Antineoplastic
Proteasome InhibitorAntineoplastic
CDSCO approvedSchedule H
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
must be excluded before
FDA category + note
Top interactionssee all 12 →
- AdalimumabSevereDatabaseDDInter
- ApalutamideSevereDatabaseDDInter
- BaricitinibSevereDatabaseDDInter
- CarbamazepineSevereDatabaseDDInter
Mechanism
Ixazomib is an inhibitor of the 26S proteasome. This action results in the down-regulation of the NF-κB signaling pathway. It also maintains activity in bortezomib-resistant tumors.
Indications
Multiple myeloma (in adults with relapsed or refractory disease who have received 2 or 3 prior lines of therapy)MM after at least one prior therapy (in combination with lenalidomide and dexamethasone)
Dosing
- Adult
- option for treating multiple myeloma in adults only if: . they have already had 2 or 3 lines of therapy, and . the conditions in the managed access agreement for ixazomib are followed.…
Pharmacokinetics
Half-life
9.5 days (elimination)
Side effects
Common
Fatiguediarrheaperipheral neuropathyhepatotoxicity
Serious
- Myelosuppression
- Neurologic toxicity with peripheral sensory neuropathy
- Diarrhea
- Hepatotoxicity
- Skin rash
Pregnancy & lactation
Pregnancy
must be excluded before
Drug interactions
Apalutamide
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Baricitinib
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Carbamazepine
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Certolizumab
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Cladribine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Clozapine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Deferiprone
Severe
Database
Clinical effect not specified
Source: DDInter
Enzalutamide
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Etanercept
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Fingolimod
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Fosphenytoin
Severe
Database
Clinical effect not specified
Source: DDInter
Related guidelines
Ask House about Ixazomib
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Sources: Goodman & Gilman 14e, BNF·Verified: 2026-05-13 · House clinical team